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PDE5 inhibitorPrescription only · Schedule H

Tadalafil

Uses, side effects, interactions and warnings

Reviewed by Dr. Rohan Kulkarni, MCh (Urology) · Updated
Generic nameTadalafil
Drug classPDE5 inhibitor
FormOral tablet
PrescriptionRequired
Starts working30–60 minutes
Lasts up to36 hours
Quick answer

Tadalafil is a prescription medicine used to treat erectile dysfunction and an enlarged prostate (BPH). It works by increasing blood flow. It must never be taken with nitrate heart medicines.

What is tadalafil used for?

  • Erectile dysfunction
  • Benign prostatic hyperplasia (enlarged prostate)
  • Pulmonary arterial hypertension (under specialist care)

How does tadalafil work?

Tadalafil blocks an enzyme called PDE5, which relaxes blood vessels and increases blood flow to the penis during sexual stimulation. It does not cause an erection on its own and does not increase desire.

How is tadalafil taken?

Tablets come in 2.5 mg, 5 mg, 10 mg and 20 mg strengths. Your doctor will decide whether you take it as needed or once daily, based on your health and other medicines. Do not take more than one dose in 24 hours.

What are the side effects of tadalafil?

Common
  • Headache
  • Indigestion
  • Back pain and muscle aches
  • Flushing
  • Stuffy nose
Get medical help right away
  • Erection lasting more than 4 hours
  • Sudden loss of vision or hearing
  • Chest pain or fainting
  • Severe allergic reaction

Which medicines interact with tadalafil?

Nitrates (nitroglycerin, isosorbide)AvoidCan cause a dangerous drop in blood pressure.
RiociguatAvoidRisk of severe low blood pressure.
Alpha-blockers (tamsulosin, doxazosin)CautionMay cause dizziness or fainting. Your doctor may adjust doses.
Ketoconazole, ritonavir and similar drugsCautionIncrease tadalafil levels in the blood.
AlcoholCautionHeavy drinking increases the risk of dizziness and low blood pressure.

Who should be careful with tadalafil?

Tell your doctor if you have heart disease, low or very high blood pressure, liver or kidney problems, a history of stroke, or a condition affecting the shape of the penis. Avoid heavy drinking while taking tadalafil, as it can lower blood pressure.

Frequently asked questions

Can women take tadalafil?

Tadalafil is not approved for treating sexual problems in women. It is sometimes prescribed for pulmonary arterial hypertension.

What is the difference between tadalafil and sildenafil?

Both are PDE5 inhibitors. Tadalafil lasts longer, up to 36 hours, while sildenafil lasts around 4 to 6 hours.

Can I take tadalafil with food?

Yes. Food does not significantly affect how tadalafil works.

This information does not replace advice from your doctor or pharmacist. SexologistIndia.com does not sell medicines.