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PDE5 inhibitorPrescription only · Schedule H

Avanafil

Uses, side effects, interactions and warnings

Reviewed by Dr. Vikram Sethi, DNB (Urology) · Updated
Generic nameAvanafil
Drug classPDE5 inhibitor
FormOral tablet
PrescriptionRequired
Starts working15–30 minutes
Lasts up toUp to 6 hours
Quick answer

Avanafil is a prescription medicine for erectile dysfunction. It is one of the fastest-acting PDE5 inhibitors, often working within 15 to 30 minutes, and lasts up to about 6 hours. Like sildenafil and tadalafil, it must never be taken with nitrate heart medicines.

What is avanafil used for?

  • Erectile dysfunction

How does avanafil work?

Avanafil blocks the PDE5 enzyme so blood vessels in the penis can relax and fill with blood during sexual arousal. It does not cause an erection without stimulation and does not increase desire.

How is avanafil taken?

Tablets come in 50 mg, 100 mg and 200 mg strengths, taken as needed about 15 to 30 minutes before sex, with or without food. Your doctor will decide the strength. Do not take more than one dose in 24 hours.

What are the side effects of avanafil?

Common
  • Headache
  • Flushing
  • Stuffy nose
  • Back pain
  • Dizziness
Get medical help right away
  • Erection lasting more than 4 hours
  • Sudden loss of vision or hearing
  • Chest pain or fainting
  • Severe allergic reaction

Which medicines interact with avanafil?

Nitrates (nitroglycerin, isosorbide)AvoidCan cause a dangerous drop in blood pressure.
Ketoconazole, ritonavir, clarithromycinAvoidGreatly raise avanafil levels.
Alpha-blockers (tamsulosin, doxazosin)CautionMay cause dizziness or fainting.
AlcoholCautionHeavy drinking increases the risk of low blood pressure.

Who should be careful with avanafil?

Tell your doctor if you have heart disease, a recent heart attack or stroke, low or uncontrolled blood pressure, or severe liver or kidney disease. It is not recommended if sex is not advised for heart reasons.

Frequently asked questions

How is avanafil different from sildenafil?

Avanafil usually starts working faster and may cause slightly fewer side effects such as visual changes. Both last a few hours.

Can I take avanafil with food?

Yes. Food has little effect on how it works, though a very heavy meal can slow it slightly.

Is avanafil available in India?

Yes, as a prescription-only medicine, usually under brand names from Indian manufacturers.

This information does not replace advice from your doctor or pharmacist. SexologistIndia.com does not sell medicines.