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ProgestogenPrescription only · Schedule H

Progesterone

Uses, side effects, interactions and warnings

Reviewed by Dr. Neha Agarwal, MS (OBG) · Updated
Generic nameProgesterone
Drug classProgestogen
FormCapsule, vaginal gel, pessary or injection
PrescriptionRequired
Quick answer

Progesterone is a natural hormone given on prescription to support early pregnancy in fertility treatment, protect the womb lining during menopause hormone therapy, and treat some menstrual problems. It comes as capsules, vaginal gel or pessaries, and injections. Drowsiness is common with oral forms.

What is progesterone used for?

  • Luteal phase support in IVF and fertility treatment
  • Protecting the womb lining in menopausal hormone therapy
  • Irregular or absent periods
  • Threatened or recurrent miscarriage (selected cases)

How does progesterone work?

Progesterone prepares and maintains the womb lining for a pregnancy and balances the effect of oestrogen on the lining. Supplementing it supports the lining when the body does not make enough.

How is progesterone used?

The form, dose and duration depend on why it is prescribed. Oral capsules are usually taken at bedtime because they can cause drowsiness. Vaginal forms are inserted once or twice a day. Your doctor will decide the plan.

What are the side effects of progesterone?

Common
  • Drowsiness or dizziness
  • Breast tenderness
  • Bloating
  • Mood changes
  • Vaginal discharge (vaginal forms)
Get medical help right away
  • Signs of a blood clot
  • Yellowing of the skin or eyes
  • Sudden severe headache or vision changes
  • Severe allergic reaction

Which medicines interact with progesterone?

Rifampicin, carbamazepine, phenytoinCautionLower progesterone levels.
Sedatives and alcoholCautionAdd to drowsiness from oral progesterone.

Who should be careful with progesterone?

Tell your doctor about unexplained vaginal bleeding, breast cancer, liver disease, blood clots or a peanut allergy (some capsules contain peanut oil). Do not drive if oral progesterone makes you drowsy.

Frequently asked questions

Why is progesterone given after IVF?

Fertility drugs can reduce your own progesterone, so extra progesterone helps the womb lining support an embryo.

Can progesterone be taken vaginally?

Yes. Vaginal gels and pessaries deliver it directly to the womb with less drowsiness.

Is progesterone the same as a progestin?

Not exactly. Progesterone is the natural hormone; progestins are synthetic versions used in some contraceptives.

This information does not replace advice from your doctor or pharmacist. SexologistIndia.com does not sell medicines.