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AntiviralPrescription only · Schedule H

Acyclovir

Uses, side effects, interactions and warnings

Reviewed by Dr. Priya Deshmukh, Venereology & Leprosy) · Updated
Generic nameAcyclovir
Drug classAntiviral
FormTablet or cream
PrescriptionRequired
Starts working1–2 days
Quick answer

Acyclovir is a prescription antiviral used to treat genital herpes outbreaks and to reduce how often they come back. It does not cure herpes, but it shortens outbreaks, eases pain and lowers the chance of passing the virus to a partner. It works best when started early.

What is acyclovir used for?

  • First and recurrent genital herpes outbreaks
  • Suppressing frequent herpes outbreaks
  • Cold sores, shingles and chickenpox

How does acyclovir work?

Acyclovir is activated inside cells infected with the herpes virus and blocks the enzyme the virus uses to copy itself. This stops the virus multiplying, so sores heal faster.

How is acyclovir used?

For an outbreak, tablets are usually taken several times a day for 5 to 10 days, started as soon as symptoms appear. For frequent outbreaks, your doctor may suggest a lower daily dose for months. Drink plenty of water while taking it.

What are the side effects of acyclovir?

Common
  • Nausea
  • Headache
  • Diarrhoea
  • Tiredness
Get medical help right away
  • Reduced urine or kidney problems
  • Confusion or hallucinations (mostly in older people or kidney disease)
  • Severe allergic reaction

Which medicines interact with acyclovir?

Medicines that affect the kidneys (some painkillers, ciclosporin)CautionHigher risk of kidney problems.
ProbenecidCautionIncreases acyclovir levels.
MycophenolateCautionBoth medicines may build up in the blood.

Who should be careful with acyclovir?

Tell your doctor about kidney disease, dehydration, or if you are pregnant or breastfeeding. Avoid sex while you have sores or warning symptoms, and use condoms between outbreaks, since herpes can spread without symptoms.

Frequently asked questions

Does acyclovir cure herpes?

No. Herpes stays in the body, but acyclovir controls outbreaks and lowers the chance of passing it on.

Should my partner be tested?

Many people carry herpes without knowing. A doctor can advise on testing and how to reduce transmission.

What is the difference between acyclovir and valacyclovir?

Valacyclovir turns into acyclovir in the body and is taken fewer times a day. Both work similarly.

This information does not replace advice from your doctor or pharmacist. SexologistIndia.com does not sell medicines.